Table 1.
Clinicopathological correlation between group I and group II uveal melanoma patients using Mann–Whitney Wilcoxon Test
| Clinicopathological parameters (N = 71) | N = 71 (%) | UM with Tumour Infiltrating Lymphocytes (Group I) N = 33 (%) | UM without Tumour Infiltrating Lymphocytes (Group II) N = 38 (%) | *p value | **p value |
|---|---|---|---|---|---|
| Largest tumor basal diameter | |||||
| ≤ 15 mm | 22 (30%) | 6 (18%) | 16 (42%) | 0.031 | 0.071 |
| > 15 mm | 49 (69%) | 27 (81%) | 22 (57%) | ||
| Tumour thickness | |||||
| ≤ 8 mm (36) | 36 (50%) | 12 (36%) | 24 (63%) | 0.025 | 0.067 |
| > 8 mm (35) | 35 (49%) | 21 (63%) | 14 (36%) | ||
| Epithelioid cell type | |||||
| Absent | 31 (43%) | 7 (21%) | 24 (63%) | < 0.001 | 0.016 |
| Present | 40 (56%) | 26 (78%) | 14 (36%) | ||
| Mitotic count | |||||
| < 4/40HPF | 43 (60%) | 12 (36%) | 31 (81%) | < 0.001 | 0.008 |
| ≥ 4/40HPF | 28 (39%) | 21 (63%) | 7 (18%) | ||
| Infiltrating macrophages | |||||
| ≤ 50% CD68 positivity | 40 (56%) | 9 (27%) | 31 (81%) | < 0.001 | 0.005 |
| > 50% CD68 positivity | 31 (43%) | 24 (72%) | 7 (18%) | ||
| Microvascular density | |||||
| ≤ 50 vessels/0.25mm2 | 38 (53%) | 12 (36%) | 26 (68%) | 0.007 | 0.022 |
| > 50 vessels/0.25mm2 | 33 (46%) | 21 (63%) | 12 (31%) | ||
| BAP1 staining | |||||
| Present | 29 (40%) | 6 (18%) | 23 (60%) | < 0.001 | 0.004 |
| Absent | 42 (59%) | 27 (81%) | 15 (39%) | ||
*p value before Benjamini–Hochberg correction
**p value adjusted after Benjamini–Hochberg correction
Bold signifies statistically significant value