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. 2021 Jan 8;70(7):1995–2008. doi: 10.1007/s00262-020-02836-w

Table 1.

Number of tumor-infiltrating immune cells per one gram of tumor core tissue

Surface marker Cell type GBM AA AO
Median 95% CI Median 95% CI Median 95% CI
CD45 +  Hematopoietic cells 1024,977 101,278 362,000 645,721 335,870 162,195
CD14-CD3 +  T cell 262,696 63,817 151,000 191,113 142,606 47,199
CD4 +  CD4 + T cell 105,000 27,542 19,043 114,850 63,261 26,029
CD4 + FoxP3 + CD25 +  Regulatory CD4 + T cell 8972 2914 1,221 11,973 697 1910
CD4 + FoxP3-CD25- Non-regulatory CD4 + T cell 87,793 24,368 14,648 102,728 60,600 22,605
CD8 +  CD8 + T cell 126,846 32,655 74,800 56,041 70,767 18,273
CD14-CD3-CD19 +  B cell 9,975 6,595 21,500 9,120 12,700 8,243
CD14-CD3-CD56 +  NK cell 9,485 4,130 6,000 6,524 12,759 12,213
CD14-CD3-CD11c +  Dendritic cell 152,000 26,999 194,000 49,896 118,000 39,564
CD14 +  Monocyte/Macrophage 146,139 34,717 17,578 433,029 26,087 38,406
CD163 +  M2-monocyte/macrophage 46,872 16,592 11,600 364,412 7,510 20,227
CD68 +  TAM 10,296 2642 338 1,625 163 8369
CD68 + CD163 +  M2-TAM 5678 1424 145 342 89 4494

GBM glioblastoma, AA anaplastic astrocytoma, AO anaplastic oligodendroglioma, CI confidence interval, TAM Tumor-associated macrophage