Table 2.

Top 10 selected features of first component of radiomic signatures for immune phenotypes and IDH genotype

Immune phenotype	Features with top 10 coefficientsa	Coefficients	p value†
T cell fraction (enriched vs deficient group)	adc_ngtdm_Strength	− 0.563	0.0012*
	ED_glcm_Imc1	0.341	0.0068*
	cbv_glszm_HighGrayLevelZoneEmphasis	0.316	0.0056*
	cbv_glszm_LowGrayLevelZoneEmphasis	− 0.316	0.0001*
	adc_glszm_SizeZoneNonUniformityNormalized	− 0.247	0.0053*
	ED_glrlm_RunEntropy	− 0.246	0.9999
	adc_glszm_GrayLevelVariance	− 0.232	0.9999
	adc_glszm_SmallAreaEmphasis	− 0.197	0.9999
	ED_shape_Sphericity	− 0.189	0.9999
	adc_glcm_MCC	− 0.187	0.9999
T cell subclass fraction (T8 vs T4* dominant group)	adc_glszm_GrayLevelVariance	− 0.499	0.0041*
	ET_gldm_DependenceVariance	− 0.456	0.033*
	ET_glcm_Idn	− 0.422	0.22
	ET_glrlm_RunPercentage	0.239	0.032*
	ET_ngtdm_Contrast	0.233	0.89
	ET_glrlm_RunLengthNonUniformityNormalized	0.227	0.043*
	ET_glrlm_ShortRunEmphasis	0.194	0.50
	ET_glcm_Idmn	− 0.194	0.048*
	ET_gldm_LargeDependenceEmphasis	− 0.179	0.52
	ET_glcm_Correlation	− 0.147	0.44
M2-TAM fraction (M2-TAM high vs low group)	adc_gldm_DependenceVariance	0.362	0.017*
	adc_firstorder_MeanAbsoluteDeviation	0.338	0.40
	ET_shape_LeastAxisLength	0.299	0.09
	adc_firstorder_RobustMeanAbsoluteDeviation	0.286	0.64
	adc_firstorder_InterquartileRange	0.282	0.25
	ED_shape_Maximum3DDiameter	0.280	0.033*
	adc_firstorder_Variance	0.261	0.079
	adc_gldm_GrayLevelVariance	0.260	0.64
	adc_glcm_ClusterTendency	0.230	0.81
	adc_glcm_InverseVariance	− 0.230	0.46
IDH genotype (IDH mut vs wt group)	cbv_shape_Sphericity	0.595	0.044*
	adc_shape_Sphericity	0.595	0.32
	cbv_glrlm_ShortRunLowGrayLevelEmphasis	− 0.268	0.69
	ET_glrlm_RunLengthNonUniformity	− 0.243	0.21
	ET_shape_SurfaceArea	− 0.203	0.06
	ET_shape_VoxelVolume	− 0.181	0.01*
	ET_shape_MeshVolume	− 0.179	0.10
	cbv_glrlm_ShortRunEmphasis	− 0.167	0.50
	ET_gldm_DependenceNonUniformity	− 0.158	0.09
	cbv_glrlm_RunEntropy	0.047	0.049*

ET features from T1-weighted contrast-enhanced images, ED features from T2-FLAIR, adc features from ADC maps, cbv features from rCBV maps, ndtdm neighbouring gray tone difference matrix, glcm gray level co-occurrence matrix, gldm gray level dependence matrix, glszm gray level size zone matrix, glrlm gray level run length matrix, shape shape features, TAM tumor-associated macrophage

^†p values of coefficients were given for information purpose only, and should be interpreted with caution, because they were computed using bootstrapping, which leads to unreliable estimation compared to the case of low-dimensional linear regression

^aSelected features are listed in descending order of absolute values of coefficients of the first component of radiomic signatures

*Indicates statistical significance (p < 0.05)