Fig. 1.

Comprehensive analysis of tumor-infiltrating immune cells and immune responses according to Fn status in MSI-high CRCs. a Comparisons of CD3⁺ T cell densities of IM (left) or CT (right) area between Fn-high and Fn-low/negative MSI-high CRCs. b Comparisons of CD8⁺ T cell densities of IM (left) or CT (right) area between Fn-high and Fn-low/negative MSI-high CRCs. c Comparisons of CD4⁺ T cell densities of IM (left) or CT (right) area between Fn-high and Fn-low/negative MSI-high CRCs. d Comparisons of FoxP3⁺ T cell densities of IM (left) or CT (right) area between Fn-high and Fn-low/negative MSI-high CRCs. e Comparisons of CD68⁺ macrophage densities of IM (left) or CT (right) area between Fn-high and Fn-low/negative MSI-high CRCs. f Comparisons of CD163⁺ macrophage densities of IM (left) or CT (right) area between Fn-high and Fn-low/negative MSI-high CRCs. g Comparisons of CD177⁺ neutrophil densities of IM (left) or CT (right) area between Fn-high and Fn-low/negative MSI-high CRCs. h A comparison of peritumoral TLS activity (maximum diameter of the largest TLS) between Fn-high and Fn-low/negative MSI-high CRCs. i A comparison of PD-L1 expression in immune cells (H-score of PD-L1 immunohistochemical staining in immune cells) between Fn-high and Fn-low/negative MSI-high CRCs. (j, k) Correlation scatter plots between Fn load and FoxP3⁺ T cell density of the IM (j) or CT (k) area in MSI-high CRCs