Fig. 4.

Lower expression of IFN-γ, CD107a by TIGIT⁺NK cells a Comparison of IFN-γ and CD107a production by TIGIT⁻ and TIGIT⁺NK cells under stimulation with rIL-12. b The negative correlation between the frequency of TIGIT expressing NK cells with IFN-γ or CD107a expression by NK cells. c Comparison of CD69 expression on TIGIT⁻ and TIGIT⁺NK cells after stimulation with rIL-12. d The correlation between the frequency of TIGIT expressing NK cells with CD69 expression on NK cells. HD, healthy donors. Each symbol represents one subject and the data are shown as the mean (± SEM). P values, unpaired two-tailed t-test a, c; the Spearman’s rank test was employed for correlation analyses (b, d), *, P < 0.05; **, P < 0.01