Table 3.

Summary of findings from the association analyses of the ImmuneSet with clinical characteristics in the ConLi⁺Gen “GWAS1” sample.

Phenotype	N	Exploratory threshold (p < 1e−4)		Suggestive GWAS threshold (p < 1e−5)			Top gene
		# SNPs	# Genes	# SNPs	# Genes	Genes	Symbol	p val
Age-at-onset	853	54	21	3	2	GRK5, PLD3	GRK5	3.9 × 10−6
# Depressive episodes	692	107	31	54	6	BLNK, PHLPP1, ZCCHC11, SACS, CPPED1, PRPF38A	BLNK	1.7 × 10−7
# Manic episodes	665	116	32	14	4	CNTN6, KALRN, LY86, PTK2B	CNTN6	2.4 × 10−6
Psychosis	692	45	13	1	1	DSCAM	DSCAM	7.6 × 10−6
Alcohol abuse	835	29	9	0	0	–	SCD5	1.8 × 10−5
Substance abuse	832	78	17	15	3	TPD52, NOD1, XKR4	TPD52	4.5 x 10−7
Suicidal ideation	660	30	7	13	1	JARID2	JARID2	3.9 × 10−6