Skip to main content
. 2024 Apr 3;15(4):243. doi: 10.1038/s41419-024-06617-6

Fig. 1. Gene set enrichment analysis reveals mitochondrial alterations in PD patients that parallel disease progression severity.

Fig. 1

A iPD in the PPMI cohort was stratified based on the evolution of the UPDRS-III score between visit 1 and visit 8. B GSEA indicates that multiple mitochondrial pathways are downregulated in iPD, at visit 1. Deregulation of mitochondrial pathways was not detected at visit 8 when pathways related to reactive oxygen species were instead upregulated. C At visit 1, patients who will develop more severe symptoms display deregulation in a higher number of mitochondrial pathways.