Table 2.

Variables related to OS in gliomas: univariate and multivariate analysis

TCGA	Univariate Cox Regression			Multivariate Cox Regression
	HR	95%CI	p Value	HR	95%CI	p Value
Age (≥ 45 vs. < 45)	5.142	3.571–7.403	< 2e–16*	2.461	1.472–4.115	0.0006*
Gender (male vs. female)	1.001	0.743–1.347	0.997
Grade (GBM vs. LGG)	9.576	6.835–13.420	< 2e–16*	1.392	0.860–2.252	0.178
IDH (wild vs. mutant type)	11.070	7.772–15.770	< 2e–16*	0.992	0.460–2.139	0.984
1p/19q (non-codel vs. codel)	4.541	2.671–7.719	2.28e–08*	1.420	0.741–2.724	0.291
MGMT promoter (unmethylated vs. methylated)	3.207	2.312–4.447	2.88e–12*	1.199	0.818–1.756	0.352
TMERS (high vs.low)	3.629	3.083–4.273	< 2e–16*	2.714	1.873–3.933	1.32e–07*

CGGA	Univariate Cox Regression			Multivariate Cox Regression
	HR	95%CI	p Value	HR	95%CI	p Value
Age (≥ 45 vs. < 45)	2.006	1.532–2.627	4.2e–07*	1.304	0.968–1.757	0.080
Gender (male vs. female)	0.998	0.759–1.312	0.988
Grade (GBM vs. LGG)	4.919	3.670–6.593	< 2e–16*	2.519	1.801–3.522	6.64e–08*
IDH (wild vs. mutant type)	2.866	2.171–3.782	1.05e–13*	0.669	0.442–1.013	0.058
1p/19q (non-codel vs. codel)	5.877	3.602–9.588	1.33e–12*	3.252	1.924–5.496	1.06e–05*
MGMT promoter (unmethylated vs. methylated)	1.195	0.911–1.566	0.199
TMERS (high vs.low)	8.733	5.951–12.810	< 2e–16*	4.036	2.258–7.215	2.51e–06*

GSE16011	Univariate Cox Regression			Multivariate Cox Regression
	HR	95%CI	p Value	HR	95%CI	p Value
Age (≥ 45 vs. < 45)	2.377	1.790–3.157	2.16e–09*	2.224	1.387–3.568	0.0009*
Gender (male vs. female)	1.066	0.811–1.401	0.647
Grade (GBM vs. LGG)	3.131	2.353–4.166	4.92e–15*	1.105	0.634–1.927	0.725
IDH (wild vs. mutant type)	1.930	1.423–2.618	2.34e–05*	1.615	0.993–2.626	0.053
1p/19q (non-codel vs. codel)	2.445	1.645–3.633	9.68e–06*	1.559	0.931–2.611	0.091
TMERS (high vs.low)	10.234	6.401–16.360	< 2e–16*	4.833	1.697–13.770	0.003*
HR, hazard ratio; CI, confidence interval; *Significant