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. 2024 Apr 3;9:83. doi: 10.1038/s41392-024-01779-3

Fig. 1.

Fig. 1

Highlights of DCIS-IDC research. Since DCIS was termed as the precursor of IDC in 1973, research on the transition from DCIS to IDC has rapidly advanced. This progress has been fueled by the establishment of in vitro DCIS cell lines and in vivo animal models. In recent years, technological advancements have offered deeper insights into the changes occurring in both tumor cells and the microenvironment during the transition from DCIS to IDC