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In vitro and in vivo models for DCIS progression research. a In vitro models, in which DCIS cell lines that include the MCF10 series,189 HMT-3522 series,191 21Tseries,193 SUM225CWN,189 SUM102PT,189 and h.DCIS.01197 authentically mimic human DCIS progression for 2D and 3D culture in vitro. b In vivo models, in which MIND models149 and GEMMs including MMTV-PyMT,233 MMTV-Neu,240 C3(1)/Tag,245 and WAP-T247 mouse are available for studying the biology of DCIS in vivo
