Table 2.

Adverse event of different anlotinib dose groups

Adverse events (n = 21)	Any grade (n, %)	Grade 1 (n, %)	Grade 2 (n, %)	Grade 3 or 4 (n, %)
Hand-foot syndrome	2 (5.00)	0	2 (5.00)	0
Hypertension	2 (5.00)	1 (2.50)	0	1 (2.50)
Hemoptysis	2 (5.00)	0	2 (5.00)	0
Thyroid dysfunction	2 (5.00)	0	2 (5.00)	0
Diarrhea	1 (2.50)	1 (2.50)	0	0
Immune hepatitis	1 (2.50)	1 (2.50)	0	0
Gastrointestinal reactions	4 (10.00)	2 (5.00)	2 (5.00)	0
Abnormal liver function	2 (5.00)	2 (5.00)	0	0
Weakness	2 (5.00)	0	2 (5.00)	0
Oral mucosa syndrome	1 (2.50)	1 (2.50)	0	0
Hyperglycemia	1 (2.50)	1 (2.50)	0	0
Immune myocarditis	1 (2.50)	0	1 (2.50)	0