Fig. 3.

Changes in immune-related genes and components within the tumor microenvironment. FPKM Fragments Per Kilobase of transcripts per Million mapped reads. a Heatmap comparison of the expression of genes related to immune suppression (immune checkpoints) and immune activation, cytolytic activity and IFN-γ-associated signature between pre-treatment and post-treatment samples by RNA sequencing. b Comparison of the absolute infiltration scores of the immune cell population estimated by CIBERSORT between pre-treatment and post-treatment samples