Table 1.
Anti-CCL20 treatment remodels the TME in orthotopic murine HNSCC
| (A) Gene-set enrichment analysis (GSEA) of hallmark gene sets after anti-CCL20 treatment | |||
|---|---|---|---|
| Upregulated | P-Value | Downregulated | P-Value |
| Interferon gamma response | 3.83E−06 | Oxidative phosphorylation | 4.40E−30 |
| MTORC1 signalling | 1.67E−04 | Adipogenesis | 2.73E−13 |
| Interferon alpha response | 1.25E−03 | Fatty acid metabolism | 3.18E−06 |
| Glycolysis | 1.93E−04 | ||
| Reactive oxygen species pathway | 2.24E−03 | ||
| Hypoxia | 2.94E−03 | ||
| Myogenesis | 9.70E−03 | ||
| Peroxisome | |||
| (B) Top differentially regulated proteins after anti-CCL20 treatment | |||||
|---|---|---|---|---|---|
| Upregulated | Fold change | P-Value | Downregulated | Fold change | P-Value |
| Ccdc124 | 2.00 | 0.0118 | Mrps25 | 2.01 | 0.0264 |
| Sart1 | 2.61 | 0.0094 | Clip1 | 1.98 | 0.0113 |
| Ipo9 | 1.54 | 0.0242 | Mtor | 1.75 | 0.0439 |
| Frg1 | 1.76 | 0.0483 | Ssbp | 1.72 | 0.0254 |
| Tm9sf2 | 1.54 | 0.0264 | |||
| Prosc | 1.54 | 0.0099 | |||
| Serpinb1a | 1.53 | 0.0103 | |||
| Gpx3 | 1.48 | 0.0190 | |||
| Prkag1 | 1.47 | 0.0298 | |||
| Prelp | 1.46 | 0.0341 | |||
| Sod1 | 1.45 | 0.0287 | |||
| Acyp1 | 1.44 | 0.0291 | |||