Table 3.
Correlation of DNMT3A mutation status with other molecular genetic mutations in intermediate karyotype.
| Gene mutation/n (%) |
DNMT3A-mutated (n=59) |
DNMT3A-wild-type (n=183) |
p value |
|---|---|---|---|
| RUNX1 | 2 (3.4) | 15 (8.2) | 0.335 |
| FLT3-ITD | 19 (32.2) | 21 (11.5) | <0.001 |
| ASXL1 | 15 (25.4) | 37 (20.2) | 0.397 |
| CEBPA bZIP | 0 (0.0) | 22 (12.0) | 0.005 |
| NPM1 | 28 (47.5) | 24 (13.1) | <0.001 |
| TP53 | 1 (1.7) | 4 (2.2) | 1.000 |
| MLL | 2 (3.4) | 12 (6.6) | 0.558 |
| KIT | 0 (0.0) | 6 (3.3) | 0.354 |
| NRAS | 9 (15.3) | 31 (16.9) | 0.762 |
| IDH1/2 | 17 (28.8) | 20 (10.9) | 0.001 |