Table 5.
Univariate and multivariate analysis of OS and RFS in AML patients.
| Variables | Univariate | Multivariate | ||||||
|---|---|---|---|---|---|---|---|---|
| OS | RFS | OS | RFS | |||||
| HR (95% CI) |
p value | HR (95% CI) |
p value | HR (95% CI) |
p value | HR (95% CI) |
p value | |
| Age (>60years) | 1.812 (1.264-2.597) |
0.001 | 1.568 (1.065-2.309) |
0.023 | 1.532 (1.065-2.205) |
0.022 | 1.361 (0.921-2.011) |
0.122 |
| WBC (≥100×109/L) | 1.928 (1.239-2.999) |
0.004 | 1.612 (1.002-2.594) |
0.049 | 2.219 (1.404-3.507) |
0.001 | 1.779 (1.094-2.893) |
0.020 |
| HB (<100 g/L) |
1.585 (0.941-2.668) |
0.083 | 1.299 (0.801-2.109) |
0.289 | ||||
| PLT (<20×109/L) | 0.992 (0.624-1.362) |
0.683 | 0.920 (0.625-1.353) |
0.671 | ||||
| LDH (≥700U/L) | 1.361 (0.952-1.946) |
0.091 | 1.078 (0.740-1.570) |
0.695 | ||||
| Adverse risk | 1.385 (0.978-1.961) |
0.067 | 1.230 (0.857-1.767) |
0.262 | ||||
| HSCT | 0.239 (0.132-0.432) |
<0.001 | 0.372 (0.231-0.598) |
<0.001 | 0.250 (0.136-0.457) |
<0.001 | 0.388 (0.239-0.630) |
<0.001 |
| CD7 | 1.187 (0.851-1.657) |
0.312 | 1.000 (0.712-1.404) |
1.000 | ||||
| DNMT3A | 1.259 (0.844-1.878) |
0.258 | 1.305 (0.871-1.955) |
0.197 | ||||
| DNMT3A-mutated/CD7+ | 2.707 (1.551-4.724) |
<0.001 | 3.329 (1.786-6.206) |
<0.001 | 1.792 (1.013-3.170) |
0.045 | 2.488 (1.320-4.689) |
0.005 |
HR, hazard ratio; CI, confidence interval; OS, overall survival; RFS, relapse-free survival; HSCT, hematopoietic stem cell transplantation.