Table 1.
Baseline characteristics of the 136 children included in the study.
| All patients (n=136) | QFT reverters (n=23) |
QFT non-reverters (n=113) | p value | |
|---|---|---|---|---|
| Age years, median [IQR] | 5.8 [3.2-11.3] | 4.4 [2.4-11.2] | 6.3 [3.6-11.3] | ns |
| <2 years | 20 (14.7) | 5 (21.7) | 15 (13.3) | ns |
| 2-5 years | 50 (36.8) | 10 (43.5) | 40 (35.4) | ns |
| >5 years | 66 (48.5) | 8 (34.8) | 58 (51.3) | ns |
| Sex female, n (%) | 55 (40.4) | 12 (52.2) | 43 (38.1) | ns |
| Region of birth | ns | |||
| African Region | 5 (3.7) | 1 (4.4) | 4 (3.5) | |
| Region of the Americas | 16 (11.8) | 3 (13) | 13 (11.5) | |
| South-East Asia Region | 3 (2.2) | 0 (0) | 3 (2.7) | |
| European Region | 105 (77.2) | 19 (82.6) | 86 (76.1) | |
| Eastern Mediterranean Region | 7 (5.1) | 0 (0) | 7 (6.2) | |
| Ethnic background | ns | |||
| White Caucasian | 94 (69.1) | 18 (78.3) | 76 (67.3) | |
| Black/African American | 8 (5.9) | 1 (4.4) | 7 (6.2) | |
| Latin American | 22 (16.2) | 4 (17.4) | 18 (15.9) | |
| Asian | 8 (5.9) | 0 (0) | 8 (7.1) | |
| Arab or Berber | 3 (2.2) | 0 (0) | 3 (2.7) | |
| Mixed race | 1 (0.7) | 0 (0) | 1 (0.9) | |
| Migrant status | ||||
| Born abroad | 35 (25.7) | 6 (26.1) | 29 (25.7) | ns |
| Born in Spain | 101 (74.3) | 17 (73.9) | 84 (74.3) | ns |
| Tuberculosis diagnosis | ||||
| TBI | 50 (36.8) | 11 (47.8) | 39 (34.5) | ns |
| TBD | 86 (63.2) | 12 (52.2) | 74 (65.5) | ns |
| Unconfirmed TB | 55 (64) | 10 (83.3) | 45 (60.8) | ns |
| Confirmed TB | 31 (36) | 2 (16.7) | 29 (39.2) | ns |
| Pulmonary | 78 (90.7) | 11 (73) | 67 (78) | ns |
| Extrapulmonary | 12 (14) | 3 (25) | 9 (16.4) | ns |
| Reported underlying condition (n=59) | 23 (39) | 5 (21.7) | 18 (78.3) | ns |
| Prematurity | 3 (13) | 2 (40) | 1 (5.6) | |
| Cardiovascular | 2 (8.7) | 1 (20) | 1 (5.6) | |
| Respiratory | 13 (56.5) | 3 (60) | 10 (55.6) | |
| Neurology | 5 (21.7) | 2 (40) | 3 (16.7) | |
| Gastrointestinal | 7 (30.4) | 2 (40) | 5 (27.8) | |
| Rheumatology | 2 (8.7) | 2 (40) | 0 (0) | |
| Nephrology | 0 (0) | 0 (0) | 0 (0) | |
| Atopic dermatitis | 2 (8.7) | 0 (0) | 2 (11.1) | |
| Haematological malignancy | 0 (0) | 0 (0) | 0 (0) | |
| Solid organ malignancy | 1 (4.3) | 0 (0) | 1 (5.6) | |
| Immune disorder | 2 (8.7) | 1 (20) | 1 (5.6) | |
| Malnutrition | 2 (8.7) | 1 (20) | 1 (5.6) | |
| BCG status (n=129) | ||||
| Yes | 26 (20.2) | 6 (23.1) | 15 (14.6) | ns |
| No | 103 (79.8) | 20 (76.9) | 88 (85.4) | ns |
Data shown are numbers and percentages unless stated otherwise. IQR, interquartile range. QFT, QuantiFERON-TB. TBI, tuberculosis infection. TBD, tuberculosis disease. BCG, Bacillus Calmette–Guérin. Comparisons were made with the chi-square test.
ns, not significant.