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. 2022 Aug 30;72(3):679–695. doi: 10.1007/s00262-022-03278-2

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© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 5 — B cell heterogeneity. A UMAP visualization of B cell subgroups. B Proportion B cell subgroups under total cells in related tissues from four patients. C Diffusion map 3D visualization showing B cell differentiation paths. D UMAP visualization of B cell clonotype frequency. E Hallmark pathway enrichment plot comparing two B cell subgroups