Comparison of DNA damage-related gene set alterations between ZFHX3-MT and ZFHX3-WT tumors in cell lines from the ICI-treated NSCLC (a), ICI-treated LUAD (b), TCGA-NSCLC (c), and TCGA-LUAD (d) cohorts. (*, P < 0.05; **, P < 0.01; ***, P < 0.001, ****, P < 0.0001, Mann–Whitney U test)