Table 1.

Multivariate and univariate analysis of OS and patient baseline characteristics

Items	No. (%)	Univariate			Multivariate
		HR	95% CI	P-value	HR	95% CI	P-value
Gender
Male	336 (81.6%)	ref	ref	ref
Female	76 (18.4%)	1.023	0.649–1.613	0.923
Age (yr.)
< 60	223 (54.1%)	ref	ref	ref
≥ 60	189 (45.9%)	1.34	0.935–1.920	0.111
BMI (kg/m2)
< 24	273 (66.3%)	ref	ref	ref	ref	ref	ref
≥ 24	139 (33.7%)	0.578	0.381–0.879	0.011	0.642	0.420–0.983	0.041
Smoking
No	86 (20.9%)	ref	ref	ref
Yes	297 (72.1%)	1.128	0.749–1.699	0.564
Alcohol
No	226 (54.9%)	ref	ref	ref
Yes	186 (45.1%)	1.034	0.800–1.388	0.796
Initial Site
supraglottic	215 (52.2%)	ref	ref	ref
glottic larynx	197 (47.8%)	1.397	0.972–2.007	0.07
Differentiation
Low–moderate	268 (65.0%)	ref	ref	ref	ref	ref	ref
high	114 (27.7%)	0.59	0.374–0.931	0.023	0.697	0.430–1.129	0.142
T-stage
T1	135 (32.3%)	ref	ref	ref	ref	ref	ref
T2	209 (50.7%)	1.536	0.982–2.401	0.059	1.452	0.625–3.372	0.386
T3	52 (12.6%)	2.314	1.328–4.031	0.003	1.182	0.426–3.286	0.748
T4	16 (3.9%)	2.24	0.927–5.410	0.073	1.068	0.215–5.315	0.936
N-Stage
N0	316 (76.7%)	ref	ref	ref	ref	ref	ref
N1	35 (8.5%)	1.302	0.672–2.521	0.434	0.656	0.236–1.824	0.42
N2	61 (14.8%)	3.297	2.195–4.954	< 0.001	1.426	0.256–7.944	0.686
TNM Stage
1	119 (28.9%)	ref	ref	ref	ref	ref	ref
2	150 (36.4%)	1.358	0.790–2.335	0.267	0.93	0.341–2.531	0.886
3	71 (17.2%)	2.175	1.217–3.888	0.008	1.937	0.580–6.460	0.282
4	72 (17.5%)	4.24	2.484–7.236	< 0.001	2.156	0.308–15.095	0.439
iTILs
Lower	226 (54.9%)	ref	ref	ref	ref	ref	ref
Higher	186 (45.1%)	0.463	0.313–0.685	< 0.001	0.502	0.338–0.746	< 0.001
TILV
Lower	126 (30.6%)	ref	ref	ref	ref	ref	ref
Higher	286 (69.4%)	0.468	0.326–0.673	< 0.001	0.462	0.318–0.672	< 0.001
TILf
Lower	142 (34.5%)	ref	ref	ref	ref	ref	ref
Higher	270 (65.5%)	0.537	0.374–0.770	< 0.001	0.585	0.405–0.845	0.004

Bold values indicate the parts that are statistically significant (P < 0.05)