Fig. 6.

Acquisition of the EMT phenotype was verified by activation of the JAK1/STAT3 signalling pathway through the CXCL2/CXCR2 signalling axis. a Western blot analysis showed that EMT occurred and the JAK1/STAT3 signalling pathway was activated by CXCL2/CXCR2 when P. gingivalis infected the TME of OSCC. b After coculture for 24 h, and the cells were transinfected with sh-CXCL2 and sh-CXCR2 lentiviruses for 72 h, the cells were observed under a fluorescence microscope. c, d Knockdown of CXCL2 and CXCR2 was verified at the protein and mRNA levels by Western blotting and qRT-PCR