Table 2.
Immunohistochemical expression of P. gingivalis, CXCL2 and TANs in samples from 140 patients with oral squamous cell carcinoma according to clinical data and follow‑up
| Variable | P. gingivalis | p | CXCL2 | p | TANs | p | |||
|---|---|---|---|---|---|---|---|---|---|
| Weak | Strong | Weak | Strong | Weak | Strong | ||||
| Gender | 0.460 | 0.795 | 0.888 | ||||||
| Male | 36 (40.9) | 52 (59.1) | 42 (47.7) | 46 (52.3) | 40 (45.5) | 48 (54.5) | |||
| Female | 18 (34.6) | 34 (65.4) | 26 (50.0) | 26 (50.0) | 23 (44.2) | 29 (55.8) | |||
| Age | 0.784 | 0.902 | 0.800 | ||||||
| < 60 years | 17 (37.0) | 29 (63.0) | 22 (47.8) | 24 (52.2) | 20 (43.5) | 26 (56.5) | |||
| ≥ 60 years | 37 (39.4) | 57 (60.6) | 46 (48.9) | 48 (51.1) | 43 (45.7) | 51 (54.3) | |||
| Living Status | < 0.001 | < 0.001 | < 0.001 | ||||||
| Living | 52 (48.1) | 56 (51.9) | 65 (60.2) | 43 (39.8) | 60 (55.6) | 48 (44.4) | |||
| Dead | 2 (6.3) | 30 (93.8) | 3 (9.4) | 29 (90.6) | 3 (9.4) | 29 (90.6) | |||
| Differentiation | 0.495 | 0.090 | 0.436 | ||||||
| Poor-moderately | 18 (42.9) | 24 (57.1) | 25 (59.5) | 17 (40.5) | 21 (50.0) | 21 (50.0) | |||
| Well | 36 (36.7) | 62 (63.3) | 43 (43.9) | 55 (56.1) | 42 (42.9) | 56 (57.1) | |||
| T Stage | < 0.001 | < 0.001 | < 0.001 | ||||||
| T1–2 | 49 (55.1) | 40 (44.9) | 62 (69.7) | 27 (30.3) | 58 (65.2) | 31 (34.8) | |||
| T3–4 | 5 (9.8) | 46 (90.2) | 6 (11.8) | 45 (88.2) | 5 (9.8) | 46 (90.2) | |||
| N Stage | < 0.001 | < 0.001 | < 0.001 | ||||||
| N0 | 34 (68.0) | 16 (32.0) | 32 (64) | 18 (36.0) | 32 (64) | 18 (36.0) | |||
| N+ | 34 (37.8) | 56 (62.2) | 31 (34.4) | 59 (65.6) | 31 (34.4) | 59 (65.6) | |||
| Clinical Stage | < 0.001 | < 0.001 | < 0.001 | ||||||
| I–II | 29 (78.4) | 8 (21.6) | 31 (83.8) | 6 (16.2) | 29 (78.4) | 8 (21.6) | |||
| III–IV | 25 (24.3) | 78 (75.7) | 37 (35.9) | 66 (64.1) | 34 (33) | 69 (67) | |||
| Recurrence | 0.153 | 0.090 | 0.422 | ||||||
| No | 43 (42.2) | 59 (57.8) | 54 (52.9) | 48 (47.1) | 48 (47.1) | 54 (52.9) | |||
| Yes | 11 (28.9) | 27 (71.1) | 14 (36.8) | 24 (63.2) | 15 (39.5) | 23 (60.5) | |||
P. gingivalis, Porphyromonas gingivalis; CXCL2, C-X-C motif chemokine ligand 2; TANs, Tumour-associated neutrophils
*p < 0.05; **p < 0.01; ***p < 0.001