FIG. 12.

Intermediate gene upstream sequences. The upstream sequences from five intermediate genes are aligned relative to the critical TAAA initiator region. The G8R, A1L, A2L, and critical (Crit) sequences are from Baldick et al. (2). The critical sequence represents nucleotides in the G8R promoter in which two of three possible substitutions decrease activity by greater than or equal to 75%. Putative core and initiator regions in the K2L and K4L sequence are underlined. Translation initiation ATGs are italicized.