Fig. 3.

TIGIT⁺CD8⁺T cells exhibit a unique suppressive function a. IFN-γ expression pattern between TIGIT⁻CD8⁺T cells and TIGIT⁺CD8⁺T cells. n = 17. b. IL-2 expression pattern between TIGIT⁻CD8⁺T cells and TIGIT⁺CD8⁺T cells. n = 14. c. TNF-α expression pattern between TIGIT⁻CD8⁺T cells and TIGIT⁺CD8⁺T cells. n = 15. d. The concentration of IFN-γ, IL-2, and TNF-α in the culture medium of TIGIT⁻CD8⁺T cells and TIGIT⁺CD8⁺T cells after culturing for 24, 48, 72 h. n = 3 biologically independent experiments. Error bars represent mean ± SEM. Two-tailed Student’s t test and paired t-test were performed for statistical analysis; ns: not significant; *P< 0.05; **p < 0.01; ***p < 0.001; ****P < 0.0001