Fig. 4.

TIGIT⁺ CD8⁺T cells exhibit a unique suppressive phenotype a. PD-1 expression pattern between TIGIT⁻CD8⁺T cells and TIGIT⁺CD8⁺T cells. n = 13. b. TIM-3 expression pattern between TIGIT⁻CD8⁺T cells and TIGIT⁺CD8⁺T cells. n = 16. c. LAG-3 expression pattern between TIGIT⁻CD8⁺T cells and TIGIT⁺CD8⁺T cells. n = 17. d. PD-1, TIM-3, LAG-3, and CD226 expression on TIGIT⁺CD8⁺T cells between normal tissues and tumors. Error bars represent mean ± SEM. Two-tailed Student’s t test and paired t-test were performed for statistical analysis; ns: not significant; *p < 0.05; **p < 0.01; ***p < 0.001; ****P < 0.0001