Fig. 1.

Percentage of baseline circulating PD-L1 + leukocytes, PD-L1 + PLTs and PMPs and plasma sPD-L1 levels in patients with advanced NSCLC and HD prior to PD-(L)1 therapy. a Representative image of PD-L1 expression (PD-L1 +) on circulating CD4 + and CD8 + T lymphocytes, CD8 + NK cells, CD14 + monocytes, Neutrophils, platelets (PLTs), and platelets microparticles (PMPs) from HD and patients with NSCLC. b Dot plots show the percentage of circulating PD-L1 + leukocytes subpopulations (HD and 119 patients with NSCLC), PLTs and PMPs (HD and 76 patients with NSCLC), and c plasma soluble PD-L1 (sPD-L1) levels (HD and 118 NSCLC patients). * p < 0.05, **p < 0.01 and ***p < 0.001