Fig. 6.

Aberrant B7-H3 expression is negatively correlated with ULBP2 expression in colon cancer patient specimens. a A representative image of the IHC or IF assay of B7-H3, ULBP2 and infiltrating γδT cell expression in neighboring noncancerous tissue (NAT) samples and colon cancer tumor tissue (CC) samples. n = 106. b B7-H3 and ULBP2 protein expression based on their staining index in NAT and CC specimens. The expression of infiltrating γδT cells was counted in NAT and CC specimens by normalizing with DAPI cells. n = 106. c The expression of B7-H3 and ULBP2 in normal solid tissue specimens (n = 41) and primary tumor specimens (n = 286) of colon cancer patients in the TCGA cohort. d The correlation between B7-H3 and ULBP2 expression in CC patient samples. n = 106. e ULBP2 protein expression is shown in patients stratified into B7-H3 low (IHC score ≤ 4, n = 76) and B7-H3 high (IHC score > 4, n = 30) groups. f γδT cell expression is shown in patients stratified into B7-H3 low (IHC score ≤ 4, n = 76) and B7-H3 high (IHC score > 4, n = 30) groups. Values are expressed as the means ± SEM. ***p < 0.001