Table 4.
Association between characteristics of patients and pericardial disease outcome
| Characteristics | Outcome | P |
|---|---|---|
| Grade at the onset | Improvement rate*, % (n/N) | |
| G4 (n = 16) | 68.8% ( 11/16) | 1.000 |
| ≤ G3 (n = 11) | 72.2% ( 8/ 11) | |
| Best response to ICI | Improvement rate, % (n/N) | |
| CR/PR (n = 15) | 66.7% (10/15) | 1.000 |
| SD/PD (n = 5) | 80.0% ( 4/ 5) | |
| Other irAEs | Improvement rate, % (n/N) | |
| Yes (n = 11) | 90.9% ( 10/11) | 0.191 |
| No (n = 17) | 64.7% ( 11/17) | |
| Malignant effusion | Improvement rate, % (n/N) | |
| Yes (n = 7) | 42.8% ( 3/ 7) | 0.053 |
| No (n = 15) | 86.7% (13/15) | |
| Pericardiocentesis/drainage/window | Improvement rate, % (n/N) | |
| Yes (n = 21) | 76.2% (16/21) | 1.000 |
| No (n = 7) | 71.4% ( 5/ 7) | |
| Steroid therapy | Improvement rate, % (n/N) | |
| Yes (n = 15) | 86.7% (13/15) | 0.197 |
| No (n = 13) | 61.5% ( 8/13) | |
| Discontinuation of ICI | Improvement rate, % (n/N) | |
| Yes (n = 18) | 72.2% ( 13/18) | 1.000 |
| No (n = 6) | 66.7% ( 4/ 6) | |
| Rechallenge of ICI | Recurrence rate, % (n/N) | |
| Yes (n = 7) | 0% ( 0/ 7) | 0.521 |
| No (n = 11) | 18% ( 2/ 11) |
*Improvement rate defined as rate of patients with full or partial recovery of pericardial disease, with no evidence of recurrence; recurrence rate defined as rate of patients with initial resolution/improvement of pericardial disease, followed by recurrent/worsening pericardial disease