. 2021 Mar 12;70(10):2925–2935. doi: 10.1007/s00262-021-02885-9

Table 2.

Correlation between expressions of UBR5, CD163 and clinicopathologic characteristics of patients with clear cell renal cell carcinoma in the training cohort (n = 186) (3:2 ratio)

Characteristic	UBR5/CD163 expression*
	UBR5^high CD163^low (n = 65)	UBR5^high CD163^high (n = 35)	UBR5^low CD163^low (n = 40)	UBR5^low CD163^high (n = 46)	Sum (186)	p** value
Age						0.239
<60	44	20	28	24	116
≥60	21	15	12	22	70
Gender						0.194
Male	41	29	27	34	131
Female	24	6	13	12	55
WHO/ISUP Grading						0.022
I–II	58	26	29	30	143
III–IV	7	9	11	16	43
TNM stage						0.003
I–II	64	27	32	36	159
III	1	8	8	10	27
SSIGN						0.004*
0-4	63	33	39	36	171
≥5	2	2	1	10	15

*UBR5^low expression: H-scores of UBR5 < 130; UBR5^high expression: H-scores of UBR5 ≥ 130; CD163^low expression: Density of CD163 < 15 cells/mm²; CD163^high expression: Density of CD163 ≥ 15 cells/mm²

**Statistical significance was calculated by Chi squared test or Fisher’s exact test for categorical/binary measures and ANOVA for continuous measures

P-value for this item is less than 0.05 and there is a statistical difference between the corresponding two groups of data