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CD27 signaling regulated IL-7Rα and PD-1 expression. IL-7Rα expression in mCAR T cells was analyzed by flow cytometry at 12 h post-co-culturing with MC38-Trop2+ (a) or LLC-Trop2+ cells (b). Early (c) and late apoptosis (d) of the co-cultured CAR T cells was detected with/without IL-7 additive. PD-1 expression was analyzed by flow cytometry in mCAR T cells at 12 h post-co-culturing with MC38-Trop2+ (e) or TIL (f). *p < 0.05, ** p < 0.01, ***p < 0.001, ****p < 0.0001
