Fig. 2.

Glycoconjugates in HCF mediate tumor protection. a C57BL/6 J mice (n = 16) were vaccinated three times at 2 week-intervals with human HCF, m-periodate oxidized HCF (mPox-HCF) or PBS in alum before LL/2 cell challenge (100,000 cells/mouse). Tumor growth was measured regularly using a caliper. Tumor volume (mm³) was calculated according to the following formula: 4/3 × pi × r1 × r2 × r3. b Survival of HCF-vaccinated and control mice was followed for 120 days after tumor challenge