Fig. 6.

Circ-HSP90A sponges miR-424-5p to up-regulate PD-L1. A Common miRNAs of circ-HSP90A and PD-L1 were predicted by starBase. B Combination between circ-HSP90A and miRNAs was measured by RNA pull down assay. C Binding sites of circ-HSP90A and miR-424-5p. D Luciferase activities of circ-HSP90A-WT and circ-HSP90A-MUT were assessed in miR-424-5p overexpressed cells. E Binding sites of PD-L1 and miR-424-5p. F Luciferase activities of PD-L1 3′UTR-WT and PD-L1 3′UTR-MUT were assessed in miR-424-5p overexpressed cells. **P < 0.01