Fig. 4.

Association between LIPH expression and somatic mutations. A KRAS, TP53, CDKN2A, and SMAD4 mutation status were significantly associated with higher expression of LIPH. B Differential expression analysis of KRAS, TP53, CDKN2A, and SMAD4 in high- and low-Exp groups in TCGA PC dataset. C Correlation matrix of KRAS, TP53, SMAD4, and CDKN2A in TCGA PC dataset. D Differential expression analysis of KRAS, TP53, CDKN2A, and SMAD4 in high- and low-Exp groups in the GSE62452 dataset. E Correlation matrix of KRAS, TP53, SMAD4, and CDKN2A in the GSE62452 dataset. (*P < 0.05; **P < 0.01;***P < 0.001; ****P < 0.0001). PC, pancreatic cancer; TCGA, the Cancer Genome Atlas; Exp, expression; Cor, Pearson correlated coefficient