Fig. 7.

ESTIMATE algorithm and ssGSEA to validate the association between LIPH expression and immune infiltration within tumors in the GSE62452 dataset. A LIPH expression positively correlated with tumor purity (Cor = 0.31, P = 0.01) and B negative correlated with immune score (Cor =  − 0.25, P = 0.04). C High LIPH expression was significantly associated with high infiltration of TAMs, D Treg cells and E Th2/Th1. (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001). TAMs, tumor-associated macrophages; Treg cells, regulatory T cells; Th1, type-1 T helper cells; type-2 T helper cells; ssGSEA, single sample gene set enrichment analysis; Exp, expression; Cor, Pearson correlated coefficient