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. 2023 Jul 12;72(10):3243–3257. doi: 10.1007/s00262-023-03490-8

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© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

In the design of CAR-M, Prof Rong Xiang and Yi Shi from Nankai University have given good suggestions. Sincere acknowledgment to them for their kindly support. Elements used for Fig.2b in this article were downloaded from https://smart.servier.com. The Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License. This work was supported by the Prospective Research Program of the Foundation for the Development of Frontier Technology of Cell Therapy of Changzhou Xitaihu (2022-P-009, Y.L.), the Fundamental Research Funds for the Central Universities (3332022181, Z.D.) and the Bilateral Inter-Governmental S&T Cooperation Project from Ministry of Science and Technology of China (2018YFE0114300, Y.L.).

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Fig.3 — CAR-M cells showed increased expression of pro-inflammatory factor. a Secretion of TNF-α in supernatant of CAR-Ms alone and CAR-Ms co-cultured with 4T1. b Secretion of IL-6 in supernatant of CAR-Ms alone and CAR-Ms co-cultured with 4T1. *P < 0.05, *** P < 0.001