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. 2022 Aug 13;9(1):82. doi: 10.1186/s40643-022-00569-5

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Fig. 3 — Schematic diagram of the biosynthesis of oxygenated taxanes with a heterologous MVA pathway. mvaE: acetoacetyl-CoA thiolase/HMG-CoA reductase gene; mvaS: HMG-CoA synthase gene; erg12: mevalonate kinase; erg8: phosphomevalonate kinase; erg19: mevalonate pyrophosphate decarboxylase; idi: IPP:DMAPP isomerase; GGPPS: geranylgeranyl pyrophosphate synthase; TS: taxadiene synthase; T5αOH-CPR: the fusion protein of taxadiene-5α-hydroxylase and Taxus-derived cytochrome P450 reductase; OCT: 5(12)-oxa-3(11)-cyclotaxane; iso-OCT: 5(13)-oxa-3(11)-cyclotaxane