Table 1.
Estimated PK parameters for untargeted LNPs
| Parameter | Bare LNPsa | IgG LNPsa |
|---|---|---|
| CLlung (mL/h) | 0.134 (16.0%) | 0.272 (15.8%) |
| CLheart (mL/h) | 0.0999 (12.3%) | 0.0976 (14.1%) |
| CLkidney (mL/h) | 0.428 (12.7%) | 0.836 (12.8%) |
| CLspleen (mL/h) | 0.656 (10.4%) | 1.41 (11.5%) |
| CLliver (mL/h) | 16.3 (9.66%) | 5.64 (13.1%) |
| CLblood (mL/h) | 1.96 (19.1%) | 5.32 (19.6%) |
| kdeg (h−1) | 1.00 (6.38%) | 1.21 (8.18%) |
CLorgan, organ uptake clearance; kdeg, intracellular first-order LNP kdeg constant.
a
Parameter estimates represented as mean (% coefficient of variation, calculated as relative standard error).