Table 3.

Estimated PK parameters for PECAM-targeted LNPs

Parameter	Estimatea
PECAMlung (μg/mL)	16.4 (7.83%)
PECAMheart (μg/mL)	1.21 (14.8%)
PECAMkidney (μg/mL)	2.56 (10.4%)
PECAMspleen (μg/mL)	2.98 (12.7%)
PECAMliver (μg/mL)	15.2 (2.90%)
CLPECAM (mL/h)	0.366 (14.9%)
KD (μg/mL)	0.00152 (51.3%)

PECAM_organ, organ-specific binding capacity for PECAM-targeted LNPs; k_PECAM, first-order internalization rate of PECAM; K_D, equilibrium dissociation constant between PECAM and PECAM-targeted LNPs.

^aParameter estimates represented as mean (% coefficient of variation calculated as relative standard error).