Fig. 6.

Spearman’s correlation analysis of TOX gene expression with expression of immunity related markers in breast cancer. a Correlation of TOX with immune checkpoint proteins, including PDCD1 (PD-1), CD274 (PD-L1), CTLA4 and LAG3. b Correlation of TOX with T cell exhaustion markers, including TIGIT, HAVCR2, LAYN, and CXCL3. c Correlation of TOX with markers of T cell effector functions, including IFN-γ, IL-2, granzyme B, and perforin. All correlations were determined by using GEPIA2 for analysis of TCGA-BRCA dataset of tumor tissues