Fig. 2.

Direct and indirect comparisons of safety among PD-L1 + Chemo, PD-1 + Chemo, and chemotherapy. The forest plots of risk ratios (RRs) for safety comparing PD-L1 + Chemo with chemotherapy, PD-1 + Chemo with chemotherapy, and PD-L1 + Chemo with PD-1 + Chemo were shown in Figure a, b, and c, individually. The horizontal line crossing the dot represents the 95% CI. All statistical tests were two-sided. Abbreviations: PD-L1, programmed cell death-ligand 1; PD-1, programmed cell death 1; Chemo, chemotherapy; AEs, adverse events; irAEs, immune-related adverse events; RR, risk ratio