Table 1.
Characteristics associated with the levels of CD8/CD39/PD-1 expression in 97 human primary ccRCC tumor samples from COHORT A
| Characteristics | All (n = 97) | Infiltrated CD8+ T-cell status | p value | |||
|---|---|---|---|---|---|---|
| Non-inflamedCD8low (n = 36) | Inflamed CD8high | |||||
| CD39low (n = 9) | CD39high PD-1low (n = 41) | CD39high PD-1high (n = 11) | ||||
| Gender, n (%) | 0.114 | |||||
| Male | 71(73.2%) | 24(66.7%) | 5(55.6%) | 34(82.9%) | 8(72.7%) | |
| Female | 26(26.8%) | 12(33.3%) | 4(44.4%) | 7(17.1%) | 3(27.3%) | |
| Age, n (%) | 0.029 | |||||
| < 60 years | 49(50.5%) | 23(63.9%) | 5(55.6%) | 16(39.0%) | 5(45.5%) | |
| ≥ 60 years | 48(49.5%) | 13(36.1%) | 4(44.4%) | 25(61.0%) | 6(54.5%) | |
| Pathological T stage, n (%) | 0.001 | |||||
| pT1 + pT2 | 58(59.8%) | 29(80.6%) | 6(66.7%) | 21(51.2%) | 2(18.2%) | |
| pT3 + pT4 | 39(40.2%) | 7(19.4%) | 3(33.3%) | 20(48.8%) | 9(81.8%) | |
| Histological grade, n (%) | < 0.001 | |||||
| G1 + G2 | 65(67.0%) | 32(88.9%) | 6(66.7%) | 25(61.0%) | 2(18.2%) | |
| G3 + G4 | 32(33.0%) | 4(11.1%) | 3(33.3%) | 16(39.0%) | 9(81.8%) | |
| Venous invasion, n (%) | 0.005 | |||||
| Yes | 40(41.2%) | 9(25%) | 5(55.6%) | 18(43.9%) | 8(72.7%) | |
| No | 57(58.8%) | 27(75%) | 4(44.4%) | 23(56.1%) | 3(27.3%) | |
| No of Foxp3+ cells/(mm2) | 19.3 ± 24.3 | 7.29 ± 14.0 | 15.5 ± 14.8 | 24.9 ± 23.2 | 40.7 ± 38.8 | < 0.001 |
| No of Foxp3+PD-1+ cells/(mm2) | 0.9 ± 3.4 | 0.2 ± 0.7 | 0.06 ± 0.1 | 0.7 ± 1.9 | 5.0 ± 8.7 | 0.001 |
| No of AE1/AE3+PD-L1+ cells/(mm2) | 1.49 ± 12.0 | 0.02 ± 0.11 | 0.04 ± 0.08 | 0.26 ± 0.86 | 12.1 ± 35.2 | 0.011 |