. 2021 Jul 14;70(10):3001–3013. doi: 10.1007/s00262-021-03006-2

Table 2.

Parameters associated with post-operative disease recurrence and overall mortality in primary ccRCC patients after adjusting univariate and multivariate Cox regression analyses in COHORT A

Characteristics	Disease recurrence						Overall mortality
	Univariate			Multivariate			Univariate			Multivariate
	Hazard ratio	95% CI	p value	Hazard ratio	95% CI	p value	Hazard ratio	95% CI	p value	Hazard ratio	95% CI	p value
Gender (male vs. female)	0.979	0.522–1.835	0.947				0.562	0.263–1.201	0.137
Age ≥ 60 vs. < 60	1.366	0.791–2.358	0.263				2.948	1.344–6.468	0.007	2.947	1.230–7.058	0.015
pT Stage (pT3,4 vs. pT1,2)	3.273	1.850–5.792	< 0.001				4.547	2.108–9.809	< 0.001
Grade (3,4 vs. 1,2)	4.050	2.309–7.103	< 0.001	2.299	1.159–4.559	0.017	5.553	2.619–11.773	< 0.001
Venous invasion (yes vs. no)	2.936	1.679–5.135	< 0.001	2.192	1.129–4.259	0.021	4.717	2.149–10.353	< 0.001	3.086	1.092–8.715	0.033
CD8⁺ T-cell heterogeneity			< 0.001			0.004			0.001
CD8^low		Reference			Reference			Reference
CD8^highCD39^low	0.396	0.052–3.052	0.374	0.217	0.028–1.712	0.147	0.000	0.000	0.976
CD8^highCD39^highPD-1^low	3.002	1.521–5.922	0.002	2.546	1.274–5.088	0.008	2.586	1.001–6.682	0.050
CD8^highCD39^highPD-1^high	7.931	3.362–18.705	< 0.001	3.262	1.260–8.446	0.015	8.063	2.836–22.925	< 0.001