. 2021 Jul 14;70(10):3001–3013. doi: 10.1007/s00262-021-03006-2

Table 3.

Parameters associated with disease progression and overall mortality in primary ccRCC patients treated with TKI (n = 38) after adjusting univariate and multivariate Cox regression analysis in COHORT A

Characteristics	Disease progression						Overall mortality
	Univariate			Multivariate			Univariate			Multivariate
	Hazard ratio	95% CI	p value	Hazard ratio	95% CI	p value	Hazard ratio	95% CI	p value	Hazard ratio	95% CI	p value
Gender (male vs. female)	0.529	0.217–1.291	0.162				0.529	0.224–1.251	0.147
Age ≥ 60 vs. < 60	3.856	1.372–10.836	0.010	3.856	1.372–10.836	0.010	2.631	1.017–6.802	0.046
pT Stage (pT3,4 vs. pT1,2)	1.791	0.746–4.301	0.192				2.498	0.982–6.356	0.055
Grade (3,4 vs. 1,2)	1.737	0.763–3.956	0.188				2.851	1.174–6.923	0.021
Venous invasion (yes vs. no)	1.695	0.731–3.929	0.219				2.401	0.988–5.838	0.053
CD8⁺ T-cell heterogeneity	2.228	0.899–5.523	0.084				2.881	1.217–6.819	0.016	3.436	1.370–8.619	0.009
(CD8^highCD39^highPD-1^high vs. CD8^highCD39^highPD-1^low)