Fig. 3.

Evolution of increased 18F-FDG thyroid uptake based on maximum standardized uptake value in the thyroid (SUVmax-Th) after the beginning of anti-PD-1 in all patients. All four patients who developed permanent hypothyroidism had an increased 18F-FDG thyroid uptake at the first restaging PET. Increased 18F-FDG thyroid uptake regressed in less than six months three out of four patients, and the fourth patient had only one PET after the onset of anti-PD-1