TABLE 4.
Phenotypes of gD variants
| Proteina | Phenotype
|
|||
|---|---|---|---|---|
| Complemen- tation of virusb | Blockage of HSV-1 entry | Blockage of plaque formation | Binding to HveAt | |
| gD1(wild type) | + | + | + | + |
| gD1(Δ290-299) | − | +++ | +++ | +++ |
| gD1(Δ277-299) | − | +++ | +++ | +++ |
| gD1(Δ277-290) | − | +++ | +++ | ++ |
| gD1(285t) | NAc | +++ | NDd | +++ |
| gD1(275t) | NA | +++ | +++ | +++ |
| gD1(234t) | NA | − | − | ± |
a
For the complementation assays, protein refers to gD in the virion envelope. For all other experiments, protein refers to truncated forms of gD produced in a baculovirus expression system.
b
From reference 3.
c
NA, not applicable.
d
ND, not done.