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. 2014 Sep 17;2014(9):CD003115. doi: 10.1002/14651858.CD003115.pub4
Ovid MEDLINE Ovid EMBASE CINAHL through EBSCOhost
Search terms for design
1. randomized controlled trial.pt.
 2. controlled clinical trial.pt.
 3. randomized controlled trial.sh.
 4. random allocation.sh.
 5. double blind method.sh.
 6. single blind method.sh.
 7. clinical trial.pt.
 8. exp clinical trial/
 9. (clin$ adj25 trial$).ti,ab.
 10. ((singl$ or doubl$ or trebl$ or tripl$) adj25 (blind$ or mask$)).ti,ab.
 11. placebos.sh.
 12. placebo$.ti,ab.
 13. random$.ti,ab.
 14. research design.sh.
 15. comparative study.sh.
 16. exp evaluation studies/
 17. follow up studies.sh.
 18. prospective studies.sh.
 19. (control$ or prospectiv$ or volunteer$).ti,ab.		 Search terms for design
1. randomized controlled trial.sh.
 2. randomization.sh.
 3. double blind procedure.sh.
 4. single blind procedure.sh.
 5. exp clinical trials/
 6. (clin$ adj25 trial$).ti,ab.
 7. ((singl$ or doubl$ or trebl$ or tripl$) adj25 (blind$ or mask$)).ti,ab.
 8. placebo.sh.
 9. placebo$.ti,ab.
 10. random$.ti,ab.
 11. methodology.sh.
 12. comparative study.sh.
 13. exp evaluation studies/
 14. follow up.sh.
 15. prospective study.sh.
 16. (control$ or prospectiv$ or volunteer$).ti,ab.		 Search terms for design
1. (MH "Clinical Trials+")
 2. (MH "Random Assignment")
 3. (MH "Double‐Blind Studies") or (MH "Single‐Blind Studies")
 4. TX (clin$ n25 trial$)
 5. TX (sing$ n25 blind$)
 6. TX (sing$ n25 mask$)
 7. TX (doubl$ n25 blind$)
 8. TX (doubl$ n25 mask$)
 9. TX (trebl$ n25 blind$)
 10. TX (trebl$ n25 mask$)
 11. TX (tripl$ n25 blind$)
 12. TX (tripl$ n25 mask$)
 13. (MH "Placebos")
 14. TX placebo$
 15. TX random$
 16. (MH "Study Design+")
 17. (MH "Comparative Studies")
 18. (MH "Evaluation Research")
 19. (MH "Prospective Studies+")
 20. TX (control$ or prospectiv$ or volunteer$)
 21. S1 or S2 or (…….) or S20
Search terms for Osteoarthritis
20. exp osteoarthritis/
 21. osteoarthriti$.ti,ab,sh.
 22. osteoarthro$.ti,ab,sh.
 23. gonarthriti$.ti,ab,sh.
 24. gonarthro$.ti,ab,sh.
 25. coxarthriti$.ti,ab,sh.
 26. coxarthro$.ti,ab,sh.
 27. arthros$.ti,ab.
 28. arthrot$.ti,ab.
 29. ((knee$ or hip$ or joint$) adj3 (pain$ or ach$ or discomfort$)).ti,ab.
 30. ((knee$ or hip$ or joint$) adj3 stiff$).ti,ab.		 Search terms for Osteoarthritis
17. exp osteoarthritis/
 18. osteoarthriti$.ti,ab,sh.
 19. osteoarthro$.ti,ab,sh.
 20. gonarthriti$.ti,ab,sh.
 21. gonarthro$.ti,ab,sh.
 22. coxarthriti$.ti,ab,sh.
 23. coxarthro$.ti,ab,sh.
 24. arthros$.ti,ab.
 25. arthrot$.ti,ab.
 26. ((knee$ or hip$ or joint$) adj3 (pain$ or ach$ or discomfort$)).ti,ab.
 27. ((knee$ or hip$ or joint$) adj3 stiff$).ti,ab.		 Search terms for Osteoarthritis
22. osteoarthriti$
 23. (MH "Osteoarthritis")
 24. TX osteoarthro$
 25. TX gonarthriti$
 26. TX gonarthro$
 27. TX coxarthriti$
 28. TX coxarthro$
 29. TX arthros$
 30. TX arthrot$
 31. TX knee$ n3 pain$
 32. TX hip$ n3 pain$
 33. TX joint$ n3 pain$
 34. TX knee$ n3 ach$
 35. TX hip$ n3 ach$
 36. TX joint$ n3 ach$
 37. TX knee$ n3 discomfort$
 38. TX hip$ n3 discomfort$
 39. TX joint$ n3 discomfort$
 40. TX knee$ n3 stiff$
 41. TX hip$ n3 stiff$
 42. TX joint$ n3 stiff$
 43. S22 or S23 or S24….or S42
Search terms for Opioids
31. exp Analgesics, Opioid/
 32. exp Narcotics/
 33. acetyldihydrocodeine.tw.
 34. alfentanil.tw.
 35. allylprodine.tw.
 36. alphamethylfentanyl.tw.
 37. alphaprodine.tw.
 38. benzylmorphine.tw.
 39. betaprodine.tw.
 40. bezitriamide.tw.
 41. buprenorphine.tw.
 42. butorphanol.tw.
 43. bremazocine.tw.
 44. carfentan$.tw.
 45. codeine.tw.
 46. contin.tw.
 47. dextromoramide.tw.
 48. dextropropoxyphene.tw.
 49. dezocine.tw.
 50. diacetylmorphine.tw.
 51. diamorphine.tw.
 52. dihydrocodeine.tw.
 53. dihydromorphine.tw.
 54. dihydromorphone.tw.
 55. diphenoxylate.tw.
 56. dipipanone.tw.
 57. enadoline.tw.
 58. ethylketazocine.tw.
 59. ethylmorphine.tw.
 60. etonitazene.tw.
 61. etorphine.tw.
 62. fentanyl.tw.
 63. heroin.tw.
 64. hydrocodone.tw.
 65. hydromorphin$.tw.
 66. hydromorphone.tw.
 67. ketazocine.tw.
 68. ketobemidone.tw.
 69. lefetamine.tw.
 70. levomethadon.tw.
 71. levomethadyl.tw.
 72. levomethorphan$.tw.
 73. levorphanol.tw.
 74. loperamide.tw.
 75. meperidine.tw.
 76. meptazinol.tw.
 77. methadone.tw.
 78. methadyl.tw.
 79. methylmorphine.tw.
 80. morphin$.tw.
 81. nalbuphine.tw.
 82. narcotic$.tw.
 83. nicocodeine.tw.
 84. nicomorphine.tw.
 85. normorphine.tw.
 86. noscapin$.tw.
 87. ohmefentanyl.tw.
 88. opiate$.tw.
 89. opioid$.tw.
 90. opium.tw.
 91. oripavine.tw.
 92. oxycodone.tw.
 93. oxycontin.tw.
 94. oxymorphone.tw.
 95. papaveretum.tw.
 96. papaverin.tw.
 97. pentazocine.tw.
 98. percocet.tw.
 99. peronine.tw.
 100. pethidine.tw.
 101. phenazocine.tw.
 102. phencyclidine.tw.
 103. pholcodine.tw.
 104. piritramid$.tw.
 105. prodine.tw.
 106. promedol.tw.
 107. propoxyphene.tw.
 108. remifentanil.tw.
 109. sufentanil.tw.
 110. tapentadol.tw.
 111. thebaine.tw.
 112. tilidine.tw.		 Search terms for Opioids
28. exp Analgesics, Opioid/
 29. exp Narcotic Analgesic Agent/
 30. acetyldihydrocodeine.tw.
 31. alfentanil.tw.
 32. allylprodine.tw.
 33. alphamethylfentanyl.tw.
 34. alphaprodine.tw.
 35. benzylmorphine.tw.
 36. betaprodine.tw.
 37. bezitriamide.tw.
 38. buprenorphine.tw.
 39. butorphanol.tw.
 40. bremazocine.tw.
 41. carfentan$.tw.
 42. codeine.tw.
 43. contin.tw.
 44. dextromoramide.tw.
 45. dextropropoxyphene.tw.
 46. dezocine.tw.
 47. diacetylmorphine.tw.
 48. diamorphine.tw.
 49. dihydrocodeine.tw.
 50. dihydromorphine.tw.
 51. dihydromorphone.tw.
 52. diphenoxylate.tw.
 53. dipipanone.tw.
 54. enadoline.tw.
 55. ethylketazocine.tw.
 56. ethylmorphine.tw.
 57. etonitazene.tw.
 58. etorphine.tw.
 59. fentanyl.tw.
 60. heroin.tw.
 61. hydrocodone.tw.
 62. hydromorphin$.tw.
 63. hydromorphone.tw.
 64. ketazocine.tw.
 65. ketobemidone.tw.
 66. lefetamine.tw.
 67. levomethadon.tw.
 68. levomethadyl.tw.
 69. levomethorphan$.tw.
 70. levorphanol.tw.
 71. loperamide.tw.
 72. meperidine.tw.
 73. meptazinol.tw.
 74. methadone.tw.
 75. methadyl.tw.
 76. methylmorphine.tw.
 77. morphin$.tw.
 78. nalbuphine.tw.
 79. narcotic$.tw.
 80. nicocodeine.tw.
 81. nicomorphine.tw.
 82. normorphine.tw.
 83. noscapin$.tw.
 84. ohmefentanyl.tw.
 85. opiate$.tw.
 86. opioid$.tw.
 87. opium.tw.
 88. oripavine.tw.
 89. oxycodone.tw.
 90. oxycontin.tw.
 91. oxymorphone.tw.
 92. papaveretum.tw.
 93. papaverin.tw.
 94. pentazocine.tw.
 95. percocet.tw.
 96. peronine.tw.
 97. pethidine.tw.
 98. phenazocine.tw.
 99. phencyclidine.tw.
 100. pholcodine.tw.
 101. piritramid$.tw.
 102. prodine.tw.
 103. promedol.tw.
 104. propoxyphene.tw.
 105. remifentanil.tw.
 106. sufentanil.tw.
 107. tapentadol.tw.
 108. thebaine.tw.
 109. tilidine.tw.		 Search terms for Opioids
44. MH " Analgesics, Opioid"
 45. MH "Narcotics"
 46. TX acetyldihydrocodeine
 47. TX alfentanil
 48. TX allylprodine
 49. TX alphamethylfentanyl
 50. TX alphaprodine
 51. TX benzylmorphine
 52. TX betaprodine
 53. TX bezitriamide
 54. TX buprenorphine
 55. TX butorphanol
 56. TX bremazocine
 57. TX carfentan$
 58. TX codeine
 58. TX contin
 60. TX dextromoramide
 61. TX dextropropoxyphene
 62. TX dezocine
 63. TX diacetylmorphine
 64. TX diamorphine
 65. TX dihydrocodeine
 66. TX dihydromorphine
 67. TX dihydromorphone
 68. TX diphenoxylate
 69. TX dipipanone
 70. TX enadoline
 71. TX ethylketazocine
 72. TX ethylmorphine
 73. TX etonitazene
 74. TX etorphine
 75. TX fentanyl
 76. TX heroin
 77. TX hydrocodone
 78. TX hydromorphin$
 79. TX hydromorphone
 80. TX ketazocine
 81. TX ketobemidone
 82. TX lefetamine
 83. TX levomethadon
 84. TX levomethadyl
 85. TX levomethorphan$
 86. TX levorphanol
 87. TX loperamide
 88. TX meperidine
 89. TX meptazinol
 90. TX methadone
 91. TX methadyl
 92. TX methylmorphine
 93. TX morphin$
 94. TX nalbuphine
 95. TX narcotic$
 96. TX nicocodeine
 97. TX nicomorphine
 98. TX normorphine
 99. TX noscapin$
 100. TX ohmefentanyl
 101. TX opiate$
 102. TX opioid$
 103. TX opium
 104. TX oripavine
 105. TX oxycodone
 106. TX oxycontin
 107. TX oxymorphone
 108. TX papaveretum
 109. TX papaverin
 110. TX pentazocine
 111. TX percocet
 112. TX peronine
 113. TX pethidine
 114. TX phenazocine
 115. TX phencyclidine
 116. TX pholcodine
 117. TX piritramid$
 118. TX prodine
 119. TX promedol
 120. TX propoxyphene
 121. TX remifentanil
 122. TX sufentanil
 123. TX tapentadol
 124. TX thebaine
 125. TX tilidine
 126. S44 or S45 or S125
Combining terms
113. or/31‐112
 114. or/1‐19
 115. or/20‐30
 116. and/113‐115
 117. animal/
 118. animal/ and human/
 119. 117 not 118
 120. 116 not 119
 121. remove duplicates from 120		 Combining terms
110. or/28‐109
 111. or/1‐16
 112. or/17‐27
 113. and/110‐112
 114. animal/
 115. animal/ and human/
 116. 114 not 115
 117. 113 not 116
 118. remove duplicates from 117		 Combining terms
127. S21 and S43 and S126