TABLE 1.
Numbers of pregnancy‐associated cancers in Sweden 1973–2017 by tumor type and by background variables.
| All deliveries | PAC during pregnancy | PAC during 0–12 months postdelivery | ||||||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | Rate/100 000 | n | % | Rate/100 000 | |
| Total (row %) | 4 557 284 | 100.0 | 1274 | 0.03 | 28.0 | 3355 | 0.07 | 73.6 |
| Tumor type | ||||||||
| All tumor types | 4629 | 100.0 | 1274 | 100.0 | 28.0 | 3355 | 100.0 | 73.6 |
| Breast | 882 | 19.1 | 212 | 16.6 | 4.7 | 670 | 20.0 | 14.7 |
| Malignant melanoma | 881 | 19.0 | 312 | 24.5 | 6.9 | 569 | 17.0 | 12.5 |
| Cervix | 647 | 14.0 | 201 | 15.8 | 4.4 | 446 | 13.3 | 9.8 |
| Ovary | 157 | 3.4 | 65 | 5.1 | 1.4 | 92 | 2.7 | 2.0 |
| Central nervous system | 341 | 7.4 | 50 | 3.9 | 1.1 | 291 | 8.7 | 6.4 |
| Colon/rectum | 214 | 4.6 | 61 | 4.8 | 1.3 | 153 | 4.6 | 3.4 |
| Thyroid | 340 | 7.3 | 58 | 4.6 | 1.3 | 282 | 8.4 | 6.2 |
| Lymphoma | 299 | 6.5 | 68 | 5.3 | 1.5 | 231 | 6.9 | 5.1 |
| Leukemia | 119 | 2.6 | 38 | 3.0 | 0.8 | 81 | 2.4 | 1.8 |
| Other | 749 | 16.2 | 209 | 16.4 | 4.6 | 540 | 16.1 | 11.8 |
| Timing of cancer diagnosis | ||||||||
| First trimester | 307 | 6.6 | 307 | 24.1 | 6.7 | |||
| Second trimester | 464 | 10.0 | 464 | 36.4 | 10.2 | |||
| Third trimester | 503 | 10.9 | 503 | 39.5 | 11.0 | |||
| 0–3 months post‐delivery | 839 | 18.1 | 839 | 25.0 | 18.4 | |||
| 3–6 months post‐delivery | 820 | 17.7 | 820 | 24.4 | 18.0 | |||
| 6–9 months post‐delivery | 822 | 17.8 | 822 | 24.5 | 18.0 | |||
| 9–12 months post‐delivery | 874 | 18.9 | 874 | 26.1 | 19.2 | |||
| Year at delivery/diagnosis | ||||||||
| 1973–1979 | 696 286 | 15.3 | 115 | 9.0 | 16.5 | 342 | 10.2 | 49.1 |
| 1980–1984 | 459 761 | 10.1 | 98 | 7.7 | 21.3 | 267 | 8.0 | 58.1 |
| 1985–1989 | 520 782 | 11.4 | 115 | 9.0 | 22.1 | 309 | 9.2 | 59.3 |
| 1990–1994 | 582 673 | 12.8 | 129 | 10.1 | 22.1 | 369 | 11.0 | 63.3 |
| 1995–1999 | 446 003 | 9.8 | 122 | 9.6 | 27.4 | 307 | 9.2 | 68.8 |
| 2000–2004 | 458 624 | 10.1 | 140 | 11.0 | 30.5 | 352 | 10.5 | 76.8 |
| 2005–2009 | 511 585 | 11.2 | 191 | 15.0 | 37.3 | 468 | 13.9 | 91.5 |
| 2010–2014 | 546 984 | 12.0 | 209 | 16.4 | 38.2 | 600 | 17.9 | 109.7 |
| 2015–2017 | 334 586 | 7.3 | 155 | 12.2 | 46.3 | 341 | 10.2 | 101.9 |
| Age at delivery/diagnosis | ||||||||
| 15–19 | 131 188 | 2.9 | 7 | 0.5 | 5.3 | 28 | 0.8 | 21.3 |
| 20–24 | 883 077 | 19.4 | 100 | 7.8 | 11.3 | 261 | 7.8 | 29.6 |
| 25–29 | 1 570 294 | 34.5 | 382 | 30.0 | 24.3 | 816 | 24.3 | 52.0 |
| 30–34 | 1 306 059 | 28.7 | 448 | 35.2 | 34.3 | 1225 | 36.5 | 93.8 |
| 35–39 | 561 175 | 12.3 | 270 | 21.2 | 48.1 | 784 | 23.4 | 139.7 |
| 40–44 | 105 491 | 2.3 | 67 | 5.3 | 63.5 | 241 | 7.2 | 228.5 |
| Live birth, gestational week | ||||||||
| 22–27 | 10 138 | 0.2 | 16 | 1.3 | 157.8 | 17 | 0.5 | 167.7 |
| 28–31 | 23 086 | 0.5 | 77 | 6.1 | 333.5 | 31 | 0.9 | 134.3 |
| 32–36 | 209 436 | 4.6 | 293 | 23.2 | 139.9 | 225 | 6.7 | 107.4 |
| 37–41 (term) | 3 922 539 | 86.4 | 821 | 65.0 | 20.9 | 2846 | 85.1 | 72.6 |
| 42+ | 366 726 | 8.1 | 53 | 4.2 | 14.5 | 219 | 6.5 | 59.7 |
| Missing gestational age | 8429 | 0.2 | 4 | 0.3 | 47.5 | 7 | 0.2 | 83.0 |
| Stillbirth, gestational week | ||||||||
| 22–27 | 1138 | 6.7 | 1 | 10.0 | 87.9 | 0 | 0.0 | 0.0 |
| 28–31 | 2610 | 15.4 | 3 | 30.0 | 114.9 | 2 | 20.0 | 76.6 |
| 32–36 | 4949 | 29.2 | 4 | 40.0 | 80.8 | 3 | 30.0 | 60.6 |
| 37–41 (term) | 7327 | 43.3 | 2 | 20.0 | 27.3 | 5 | 50.0 | 68.2 |
| 42+ | 752 | 4.4 | 0 | 0.0 | 0.0 | 0 | 0.0 | 0.0 |
| Missing gestational age | 154 | 0.9 | 0 | 0.0 | 0.0 | 0 | 0.0 | 0.0 |
| Parity prior to current delivery | ||||||||
| 0 | 1 948 329 | 42.8 | 527 | 41.4 | 27.0 | 1225 | 36.5 | 62.9 |
| 1 | 1 664 925 | 36.5 | 449 | 35.2 | 27.0 | 1263 | 37.6 | 75.9 |
| 2+ | 944 030 | 20.7 | 298 | 23.4 | 31.6 | 867 | 25.8 | 91.8 |
| Immigrant status | ||||||||
| Non‐immigrant | 3 778 450 | 82.9 | 1083 | 85.0 | 28.7 | 2815 | 83.9 | 74.5 |
| Immigrant | 778 544 | 17.1 | 191 | 15.0 | 24.5 | 540 | 16.1 | 69.4 |
| Missing | 290 | 0.0 | 0 | 0.0 | 0.0 | 0 | 0.0 | 0.0 |
| Education level (1990–2017) | ||||||||
| <10 years | 365 994 | 12.7 | 91 | 9.5 | 24.9 | 239 | 9.9 | 65.3 |
| 10–13 years | 1 286 121 | 44.6 | 385 | 40.4 | 29.9 | 995 | 41.1 | 77.4 |
| Undergraduate | 403 519 | 14.0 | 131 | 13.7 | 32.5 | 361 | 14.9 | 89.5 |
| Postgraduate | 755 377 | 26.2 | 337 | 35.3 | 44.6 | 788 | 32.6 | 104.3 |
| Missing | 69 444 | 2.4 | 10 | 1.0 | 14.4 | 35 | 1.4 | 50.4 |
| Smoking (1990–2017) | ||||||||
| No | 2 250 613 | 78.1 | 707 | 74.1 | 31.4 | 1930 | 79.8 | 85.8 |
| Yes | 482 938 | 16.8 | 157 | 16.5 | 32.5 | 350 | 14.5 | 72.5 |
| Missing | 146 904 | 5.1 | 90 | 9.4 | 61.3 | 138 | 5.7 | 93.9 |
| Pre‐pregnancy BMI (1990–2017) | ||||||||
| <18.5 kg/m2 | 61 526 | 2.1 | 19 | 2.0 | 30.9 | 47 | 1.9 | 76.4 |
| 18.5–24.9 kg/m2 | 1 449 117 | 50.3 | 467 | 49.0 | 32.2 | 1243 | 51.4 | 85.8 |
| 25.0–29.9 kg/m2 | 567 575 | 19.7 | 202 | 21.2 | 35.6 | 505 | 20.9 | 89.0 |
| ≥30.0 kg/m2 | 255 824 | 8.9 | 77 | 8.1 | 30.1 | 205 | 8.5 | 80.1 |
| Missing | 546 413 | 19.0 | 189 | 19.8 | 34.6 | 418 | 17.3 | 76.5 |