TABLE 3.
All tumor types | Malignant melanoma | Breast | Cervix | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
n | IRR a | 95% CI | n | IRR a | 95% CI | n | IRR a | 95% CI | n | IRR a | 95% CI | |
Year at delivery/diagnosis | ||||||||||||
1990–1994 | 369 | 1.00 | Ref | 62 | 1.00 | Ref | 74 | 1.00 | Ref | 39 | 1.00 | Ref |
1995–1999 | 307 | 1.01 | 0.87–1.18 | 49 | 0.95 | 0.65–1.38 | 58 | 0.88 | 0.62–1.24 | 32 | 1.02 | 0.64–1.63 |
2000–2004 | 352 | 1.05 | 0.91–1.22 | 63 | 1.10 | 0.77–1.56 | 60 | 0.77 | 0.55–1.08 | 54 | 1.61 | 1.06–2.44 |
2005–2009 | 468 | 1.22 | 1.06–1.40 | 78 | 1.20 | 0.85–1.68 | 113 | 1.20 | 0.89–1.62 | 54 | 1.48 | 0.97–2.26 |
2010–2014 | 600 | 1.49 | 1.30–1.70 | 127 | 1.89 | 1.38–2.59 | 130 | 1.28 | 0.96–1.73 | 75 | 2.03 | 1.36–3.03 |
2015–2017 | 341 | 1.39 | 1.20–1.62 | 75 | 1.88 | 1.33–2.66 | 65 | 1.05 | 0.74–1.48 | 47 | 2.13 | 1.38–3.30 |
P < 0.0001 | P < 0.0001 | P = 0.0136 | P = 0.0006 | |||||||||
Age at delivery/diagnosis | ||||||||||||
15–24 | 161 | 0.33 | 0.27–0.39 | 22 | 0.28 | 0.18–0.45 | 4 | 0.04 | 0.02–0.11 | 18 | 0.22 | 0.13–0.36 |
25–29 | 525 | 0.55 | 0.49–0.62 | 110 | 0.64 | 0.50–0.82 | 58 | 0.30 | 0.22–0.40 | 71 | 0.48 | 0.36–0.64 |
30–34 | 929 | 1.00 | Ref | 171 | 1.00 | Ref | 193 | 1.00 | Ref | 139 | 1.00 | Ref |
35–39 | 617 | 1.44 | 1.29–1.59 | 117 | 1.52 | 1.20–1.93 | 181 | 2.00 | 1.63–2.46 | 63 | 0.98 | 0.73–1.33 |
40–44 | 205 | 2.43 | 2.09–2.84 | 34 | 2.34 | 1.61–3.40 | 64 | 3.58 | 2.68–4.77 | 10 | 0.79 | 0.42–1.51 |
P < 0.0001 | P < 0.0001 | P < 0.0001 | P < 0.0001 | |||||||||
Parity prior to current delivery | ||||||||||||
0 | 921 | 1.00 | Ref | 186 | 1.00 | Ref | 155 | 1.00 | Ref | 115 | 1.00 | Ref |
1 | 922 | 0.96 | 0.88–1.06 | 181 | 0.93 | 0.76–1.15 | 198 | 1.04 | 0.84–1.28 | 117 | 0.98 | 0.75–1.27 |
2+ | 594 | 0.90 | 0.80–1.00 | 87 | 0.72 | 0.55–0.95 | 147 | 0.95 | 0.75–1.21 | 69 | 0.89 | 0.64–1.23 |
Not counting index birth | P = 0.1555 | P = 0.0607 | P = 0.7523 | P = 0.7609 | ||||||||
Immigrant status | ||||||||||||
Non‐immigrant | 1998 | 1.00 | Ref | 424 | 1.00 | Ref | 391 | 1.00 | Ref | 262 | 1.00 | Ref |
Immigrant | 439 | 0.83 | 0.75–0.92 | 30 | 0.27 | 0.19–0.39 | 109 | 1.07 | 0.86–1.33 | 39 | 0.53 | 0.38–0.75 |
Imputed | 0 | 0 | 0 | 0 | ||||||||
P = 0.0006 | P < 0.0001 | P = 0.5704 | P = 0.0004 | |||||||||
Education | ||||||||||||
<10 years | 239 | 0.98 | 0.84–1.13 | 27 | 0.85 | 0.56–1.29 | 38 | 0.82 | 0.57–1.18 | 36 | 1.20 | 0.81–1.75 |
10–13 years | 995 | 1.00 | Ref | 172 | 1.00 | Ref | 189 | 1.00 | Ref | 140 | 1.00 | Ref |
Undergraduate | 361 | 0.95 | 0.84–1.08 | 84 | 1.25 | 0.96–1.63 | 81 | 0.98 | 0.75–1.27 | 35 | 0.67 | 0.46–0.97 |
Postgraduate | 788 | 0.92 | 0.83–1.02 | 167 | 1.03 | 0.81–1.30 | 182 | 0.92 | 0.74–1.15 | 87 | 0.70 | 0.52–0.93 |
Imputed | 54 | 4 | 10 | 3 | ||||||||
P = 0.4208 | P = 0.2622 | P = 0.6897 | P = 0.0159 | |||||||||
Cigarette smoking | ||||||||||||
No | 1930 | 1.00 | Ref | 377 | 1.00 | Ref | 414 | 1.00 | Ref | 237 | 1.00 | Ref |
Yes | 350 | 1.02 | 0.91–1.14 | 50 | 0.84 | 0.62–1.14 | 51 | 0.78 | 0.58–1.05 | 52 | 1.08 | 0.79–1.48 |
Imputed | 157 | 27 | 35 | 12 | ||||||||
P = 0.7710 | P = 0.2583 | P = 0.1007 | P = 0.6298 | |||||||||
Pre‐pregnancy BMI | ||||||||||||
<18.5 | 47 | 1.11 | 0.82–1.48 | 6 | 0.76 | 0.33–1.71 | 8 | 1.09 | 0.52–2.27 | 7 | 1.30 | 0.61–2.77 |
18.5–24.9 | 1243 | 1.00 | Ref | 244 | 1.00 | Ref | 244 | 1.00 | Ref | 158 | 1.00 | Ref |
25.0–29.9 | 505 | 0.98 | 0.88–1.09 | 96 | 1.01 | 0.78–1.30 | 103 | 0.99 | 0.78–1.25 | 71 | 1.09 | 0.83–1.44 |
30.0+ | 205 | 0.86 | 0.74–1.00 | 36 | 0.84 | 0.58–1.20 | 46 | 0.97 | 0.71–1.32 | 28 | 0.90 | 0.60–1.35 |
Imputed | 437 | 72 | 99 | 37 | ||||||||
P = 0.2118 | P = 0.6963 | P = 0.9908 | P = 0.7497 | |||||||||
Cases with information imputed, total | 485 | 81 | 108 | 43 |
Model included year, age, parity, immigration status, education, smoking and body mass index (BMI). Education, smoking and BMI imputed using MICE, 10 cycles of chained equations and 30 sets.