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. 2024 Apr 4;5(4):e519. doi: 10.1002/mco2.519

TABLE 1.

Major TFS and their related genes in the regulation of redox homeostasis.

TFs Related genes that interact to regulate redox homeostasis References
NRF2 Keap1, STAT3, HO‐1, TIGAR, AMPK, KRAS, NRG1, PRAK, p53 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81
HIF‐1a PHD, FIH‐1, COX, LON, NDUFA4L2, ELAVL1, HO‐1 82 , 83 , 84 , 85 , 86 , 87
FOXO AKT, JNK, SIRT1, AMPK, transporting 1 88 , 89 , 90 , 91 , 92
BACH1 NRF2, HO‐1, AKT, mTOR, c‐Myc 93 , 94 , 95 , 96

Abbreviations: AKT: protein kinase B; AMPK: AMP‐activated kinase; BACH1: The BTB and CNC homology 1; COX: cytochrome c oxidase; FOXO: forkhead box O; HO‐1: heme oxygenase‐1 signaling; HIF‐1a: hypoxia‐inducible transcription factors; JNK: c‐jun N‐terminal kinase; Keap1: kelch‐like ECH‐associated protein 1; mTOR: mammalian target of rapamycin; NRG1: neuregulin 1; NRF2: nuclear factor erythroid 2‐related factor 2; PRAK: p38‐regulated/activated protein kinase; PHD: prolyl hydroxylase domain protein; STAT3: signal transducer and activator of transcription 3; SIRT1: sirtuin 1; TFs: transcription factors; TIGAR: TP53‐induced glycolysis and apoptosis regulator.