TABLE 1.
TFs | Related genes that interact to regulate redox homeostasis | References |
---|---|---|
NRF2 | Keap1, STAT3, HO‐1, TIGAR, AMPK, KRAS, NRG1, PRAK, p53 | 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 |
HIF‐1a | PHD, FIH‐1, COX, LON, NDUFA4L2, ELAVL1, HO‐1 | 82 , 83 , 84 , 85 , 86 , 87 |
FOXO | AKT, JNK, SIRT1, AMPK, transporting 1 | 88 , 89 , 90 , 91 , 92 |
BACH1 | NRF2, HO‐1, AKT, mTOR, c‐Myc | 93 , 94 , 95 , 96 |
Abbreviations: AKT: protein kinase B; AMPK: AMP‐activated kinase; BACH1: The BTB and CNC homology 1; COX: cytochrome c oxidase; FOXO: forkhead box O; HO‐1: heme oxygenase‐1 signaling; HIF‐1a: hypoxia‐inducible transcription factors; JNK: c‐jun N‐terminal kinase; Keap1: kelch‐like ECH‐associated protein 1; mTOR: mammalian target of rapamycin; NRG1: neuregulin 1; NRF2: nuclear factor erythroid 2‐related factor 2; PRAK: p38‐regulated/activated protein kinase; PHD: prolyl hydroxylase domain protein; STAT3: signal transducer and activator of transcription 3; SIRT1: sirtuin 1; TFs: transcription factors; TIGAR: TP53‐induced glycolysis and apoptosis regulator.