Table 3.

Echocardiographic data

	AC + MRT (n = 132)	AC alone (n = 114)	Controls (n = 58)	p-value (ANOVA)	p-value AC + MRT vs. AC alone	p-value AC + MRT vs. controls	p-value AC alone vs. controls
Morphology
LA volume, mL/m2	25 ± 6	27 ± 8	29 ± 7	0.016	0.56	0.012	0.31
IVSd, mm	8.8 ± 2.0	9.1 ± 1.8	9.2 ± 1.8	0.33	0.74	0.57	1.00
LVIDd, mm	47 ± 6	50 ± 5	49 ± 6	< 0.001	< 0.001	0.027	0.92
LVPWd, mm	7.8 ± 1.4	8.2 ± 1.3	8.3 ± 1.4	0.012	0.043	0.035	1.00
LV Mass, g/m2	67 ± 17	76 ± 18	76 ± 18	0.002	0.004	0.013	1.00
3D LV EDV, mL/m2	60 ± 9	64 ± 10	65 ± 10	0.012	0.09	0.015	1.00
3D LV ESV, mL/m2	25 ± 6	28 ± 6	27 ± 5	0.06	0.06	0.45	1.00
RA area, cm2/m2	16 ± 3	17 ± 3	17 ± 3	0.06	0.15	0.14	1.00
RV end-diastolic area, cm2/m2	9.3 ± 1.5	9.6 ± 1.7	9.9 ± 1.6	0.18	0.05	0.34	1.00
RV end-systolic area, cm2/m2	5.6 ± 1.1	6.0 ± 1.1	5.8 ± 1.0	0.11	0.020	0.85	0.29
Systolic function
3D LV EF, %	58 ± 5	57 ± 5	59 ± 4	0.13	1.00	0.32	0.15
3D LV SI, mL/m2	35 ± 5	36 ± 6	39 ± 6	0.004	0.49	0.002	0.14
LV GLS, %	19.3 ± 2.5	20.2 ± 2.6	20.8 ± 2.0	< 0.001	0.034	< 0.001	0.34
RV FAC, %	40 ± 7	39 ± 6	41 ± 7	0.28	0.81	1.00	0.39
TAPSE, mm	22 ± 3	22 ± 3	24 ± 3	0.001	1.00	0.002	0.004
Diastolic function
Mitral E velocity, cm/sec	67 ± 18	63 ± 15	65 ± 14	0.13	0.13	1.00	1.00
Mitral A velocity, cm/sec	60 ± 16	54 ± 14	51 ± 15	< 0.001	0.18	0.001	0.56
Mitral E/A-ratio	1.2 ± 0.4	1.2 ± 0.4	1.4 ± 0.4	0.009	0.92	0.007	0.08
Mitral DT, ms	175 ± 47	187 ± 52	161 ± 46	0.005	0.22	0.22	0.004
E/e’-ratio	7.7 ± 2.4	7.1 ± 2.8	6.9 ± 1.8	0.06	0.20	0.11	1.00
TR velocity, m/s	23 ± 3	23 ± 3	23 ± 2	0.99	1.00	1.00	1.00

Data expressed as mean ± SD for parametric data and median (IQR) for non-parametric data. P-values derived from simple one-way ANOVA for continual, parametric data and Kruskal-Wallis one-way ANOVA for continual, non-parametric data. Comparison between individual groups performed with the Bonferonni correction for multiple comparisons