Table 2.

Exploring the associations between serum cotinine levels and cardiovascular disease risk

Exposure	Non-adjusted OR (95%CI) P-value	Adjust I OR (95%CI) P-value	Adjust II OR (95%CI) P-value
Log Cotinine	1.05 (1.01, 1.10) 0.0273	1.21 (1.14, 1.27) < 0.0001	1.25 (1.18, 1.33) < 0.0001
Log Cotinine (quartile)
Q1	Ref	Ref	Ref
Q2	0.81 (0.63, 1.04) 0.0979	0.97 (0.74, 1.28) 0.8393	0.94 (0.69, 1.27) 0.6733
Q3	0.89 (0.71, 1.10) 0.2854	1.25 (0.99, 1.60) 0.0654	1.16 (0.89, 1.52) 0.2683
Q4	1.06 (0.86, 1.31) 0.5698	2.07 (1.63, 2.64) < 0.0001	2.33 (1.77, 3.07) < 0.0001
P for trend	0.6010	< 0.0001	< 0.0001

Non-adjusted model adjust for: None

Adjust I model adjust for: Sex; Age; Race

Adjust II model adjust for: Sex; Age; Race; SBP; DBP; BMI; Waist; HDL-c; TG; LDL-c; TC; HbA1c; FPG; A; ALT; AST; BUN; CR; TB; UA; Alcohol; HTN; DM; CKD; Anti-platelet; β-blockers; ACEI/ARB; Statin; Diuretic; Anticoagulant